PAHs (Polycyclic aromatic compounds)

Hi there, 

You should also look at transfer line temperature which needs to be higher than normal. This link may give some additional ideas on things to try like pulsed splitless
https://www.agilent.com/cs/library/brochures/brochure_pah_food_gc-ms-ms_5994-2016en_agilent.pdf

Do remember to check the temperature limits for your GC and MS as they can vary from model to model
Kevin

I always question the need for dramatically higher than normal transferline temperatures. The column piece inside is essentially at the full vacuum of the MS and so the boiling points of all compounds are significantly lower.   250°C transferline temperature under vacuum means the atmospheric boiling point of the compound could be 600°C.

That said, It makes some sort of sense to run the transferline at the same temperature as the ion source to help the ion source thermal stability.

I always question the need for dramatically higher than normal transferline temperatures. The column piece inside is essentially at the full vacuum of the MS and so the boiling points of all compounds are significantly lower.   250°C transferline temperature under vacuum means the atmospheric boiling point of the compound could be 600°C.

That said, It makes some sort of sense to run the transferline at the same temperature as the ion source to help the ion source thermal stability.