Increased Response

I have an Agilent 6890N GC with a 5975B MS. All of a sudden, the responses have dramatically increased with no change to the system or method. Any ideas what would cause responses to increase suddenly?

  • What happened last? Was the carrier gas tank replaced? Ion source cleaned? Inlet maintenance performed? Liner replaced?  Anything at all?

    Did the tune change dramatically?  Did the Electron Multiplier voltage increase from before the issue to now?

    Are you running split, splitless, or pulsed splitless injections?

    Are you using an automatic liquid sampler?  Did you watch it during injection to make sure it's only pulling up to the right stop/location?

    Did the responses increase all the same amount on all compounds and all runs?

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