Sensitivity and Resolution Captan and Coumaphos

Question

Hi! 
 I have a GCMSMS TQ (8990GC/7010B GCTQ) and developing a Pesticides method. Captan and Coumaphos recoveries (responses)/resolution in the lower half of the calibration is bad to non existence. Using CF,20 min method and AP with sandwich technique. Other compounds look good. Any suggestions on how to improve the sensitivity/resolution for those 2? 
 Thanks

paulsalverda · Answer

Captan is a difficult compound even when things are perfect. The pH of the sample is important. Check out: application-california-cannabis-pesticides-gc-ms-ms-5994-1019en-agilent.pdf and Analysis of Challenging Pesticides Regulated in the Cannabis and Hemp Industry with the Agilent Intuvo 9000‑7010 GC/MS/MS system: The Fast-5

Sensitivity and Resolution Captan and Coumaphos

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