MSD lowest parameters for leak searching

Yes.  Cold.M using Cold.U -- a method and tune file with the heaters all set to off or something like 40 C, are very useful.

Remember that as little as a few ppm of oxygen can damage a column or kill the inertness of the liner if those parts are hot - even 100C is a bit too hot for the liner and column, in my experience.

40% turbo pump speed is higher than recommended to remove the column from the MS.  It's not horrible if the column is still installed in the MS and you were only working at the Thermal Desorber/inlet/column connection, because the total flow to the MS would be restricted by the column.

Switching the column every two weeks must be tedious, but honestly a full vent, removal, change, pumpdown, check is the best way.  There is hardware to make it easier if you need to change it more often, but those come with compromises.  Make sure and use the Finger Tight column nut and short ferrule on the MSD transferline connection.

Yes.  Cold.M using Cold.U -- a method and tune file with the heaters all set to off or something like 40 C, are very useful.

Remember that as little as a few ppm of oxygen can damage a column or kill the inertness of the liner if those parts are hot - even 100C is a bit too hot for the liner and column, in my experience.

40% turbo pump speed is higher than recommended to remove the column from the MS.  It's not horrible if the column is still installed in the MS and you were only working at the Thermal Desorber/inlet/column connection, because the total flow to the MS would be restricted by the column.

Switching the column every two weeks must be tedious, but honestly a full vent, removal, change, pumpdown, check is the best way.  There is hardware to make it easier if you need to change it more often, but those come with compromises.  Make sure and use the Finger Tight column nut and short ferrule on the MSD transferline connection.