High RSD with injections from same vial

Jodie 2 days ago

Hi I am having precision issues with RSD of up 20% for injections from same vial for MDMA and diphenylamine. I am at method development stage and have changed septum, syringe and liner but have had no improvement. Can anyone suggest anything I can try?

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0 paulsalverda 2 days ago

Under your method's Windows ***.D subdirectory is a file called "acqmeth.txt" that has all of the GC parameters, please share it. What is the injection solvent? What sample prep? Autosampler or manual injection? When you change the liner was it clean or were there little red particles of septum inside that result from an overtightened septum? What is the RSD for a known standard like one of the instrument checkout samples using a known good method?

See: (+) Proving that an Agilent GC/MS system is fully functional - Files - GC/MS - Agilent Community
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0 paulsalverda 2 days ago

Under your method's Windows ***.D subdirectory is a file called "acqmeth.txt" that has all of the GC parameters, please share it. What is the injection solvent? What sample prep? Autosampler or manual injection? When you change the liner was it clean or were there little red particles of septum inside that result from an overtightened septum? What is the RSD for a known standard like one of the instrument checkout samples using a known good method?

See: (+) Proving that an Agilent GC/MS system is fully functional - Files - GC/MS - Agilent Community
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