Hi everyone,
I am working on trace analysis of volatile organic compounds (VOCs) using a gas chromatograph (Agilent 7890B) and am trying to optimize the split ratio for my method. I understand that a lower split ratio can help concentrate the sample on the column, which is crucial for detecting trace levels of VOCs. However, I am concerned about potential issues like overloading the column or affecting peak shape and resolution.
Does anyone have experience balancing split ratio for sensitive trace analysis: ?? What factors should I consider when deciding on the optimal split ratio: ??
For instance, is there a recommended range I should start with, or specific signs that indicate I might need to adjust: ??
Also, how does the type of column or detector (I am using an FID) influence the choice of split ratio: ??
Any insights or tips from your own experience would be greatly appreciated....! I also read this thread https://community.agilent.com/technical/gc/f/forum/2055/we-have-a-gc-method-with-a-spit-ratio-of-0-2-1-i-thought-that-was-impossible-how-is-it-that-this-split-ratio-is-acceptable-cissp/ for but now I am looking for more advice and tips.
Thanks in advance!
Mitchel Johnsons