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dichloromethane GC syringe compatability

pstaunton

hi,

were currently working on a project to reduce the amount of syringe related issues when running GC assays. however once every so often our syringe will stop pulling liquid into the barrel. the syringe is a 10ul gold standard syringe with PTFE plunger. 

the wash solvents are acetonitrile and the injection volume is 1ul

we inject alot of samples that are dissolved in dichloromethane. dichloromethane is a very aggressive solvent and may be destroying the PTFE over time and wearing away the seal between the barrel and plunger? if so would a syringe without PTFE be better. any other suggestions are welcome

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  • +1

    Dichloromethane is not only degrading PTFE, but - more importantly - possible glue connection in the syringe. After injecting DCM samples use acetonitrile and/or acetone 10 times to clean the syringe.

    Another option is the use of plunger-in-needle syringes, where the sample stays in the metal needle. Still DCM can contain minute amouts of HCl that will corode the metal.

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  • +1

    Dichloromethane is not only degrading PTFE, but - more importantly - possible glue connection in the syringe. After injecting DCM samples use acetonitrile and/or acetone 10 times to clean the syringe.

    Another option is the use of plunger-in-needle syringes, where the sample stays in the metal needle. Still DCM can contain minute amouts of HCl that will corode the metal.

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