ICP-MS Validation

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How does one go about demonstrating selectivity with ICP-MS? Is there perhaps a validation protocol available for ICP-MS.

Thank you.

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  • Selectivity/specificity- the ability to asses/distinguish the analyte clearly from the presence of other components expected to be present.

    With HPLC the analyte could be submitted to elevated temp for long periods, low pH or high pH conditions etc, and the analyte peak should be distinguished from any other formed breakdown products or excipients.

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