Optimizing Pump Compressibility Compensation Setting

Version 1

    The compressibility compensation default setting is 100 × 10-6 /bar for the

    pump. This setting represents an average value. Under normal conditions the

    default setting reduces the pressure pulsation to values (below 1% of system

    pressure) that will be sufficient for most applications and for all gradient

    analyses. For applications using sensitive detectors, the compressibility

    settings can be optimized by using the values for the various solvents

    described in Table 9 on page 61. If the solvent in use is not listed in the

    compressibility tables, when using isocratic mixtures of solvents and if the

    default settings are not sufficient for your application the following procedure

    can be used to optimize the compressibility settings.