Separation of Beta Blockers at Low and High pH Using Agilent Poroshell HPH C18

Version 1

    Application Note

    Small Molecule Pharmaceuticals

     

    Abstract

    Beta blockers, or beta-adrenergic blocking agents, are a class of drugs used to treat hypertension and to manage cardiac arrhythmias. As beta adrenergic receptor antagonists, they diminish the effects of epinephrine (adrenaline) and other stress hormones by blocking their binding to beta receptors on nerve endings. The first beta blocker was synthesized in 1958 by Eli Lilly Laboratories, but in 1962 the first clinically significant beta blockers, propranolol and pronethalol, were developed and used for the treatment of angina pectoris.

     

    Publication number: 5991-6519EN

    Publication Date: December 7, 2015

     

    http://www.agilent.com/cs/library/applications/5991-6519EN.pdf