This Application Note demonstrates the use of the Agilent 1260 Infinity Analytical SFC System for the separation of a library of polar pharmaceutical compounds. It is focused on the larger number of beta-blockers included in the used library. For all beta-blockers, performance data such as linearity, limit of detection (LOD) and limit of quantification (LOQ), and retention time and area RSDs are discussed. Finally, a urine sample spiked with a beta-blocker was measured.
Publication number: 5991-6437EN.pdf
Publication Date: December 1, 2015