Determination of Beta-Blockers in Urine Using Supercritical Fluid Chromatography and Mass Spectrometry

Version 3

    Application Note

    Doping Control

     

    Abstract

    This Application Note demonstrates the use of the Agilent 1260 Infinity Analytical SFC System for the separation of a library of polar pharmaceutical compounds. It is focused on the larger number of beta-blockers included in the used library. For all beta-blockers, performance data such as linearity, limit of detection (LOD) and limit of quantification (LOQ), and retention time and area RSDs are discussed. Finally, a urine sample spiked with a beta-blocker was measured.

     

    Publication number: 5991-6437EN.pdf

    Publication Date: December 1, 2015

     

    http://www.agilent.com/cs/library/applications/5991-6437EN.pdf