A gas chromatography-triple quadrupole mass spectrometer ( GC-MS/MS) method has been developed for the determination of 17 organotin compounds in beverages. the sample was derivatized with NaBEt4 and used liquid-liquid extraction with hexane. Data were acquired in the MRM mode and an external standard was used for quantitative determination. calibration curves were generated for all the derivatized compounds with concentrations for most of them ranging from 0.001mg/L to 0.200mg/L. Samples were concentrated by a factor of 10 during preparation and so the working range for the method was effectively 0.0001mg/L to 0.0200mg/L. Correlation coefficients for all of the calibration curves were higher than 0.995. recoveries were determined for three replicate extractions at two spike levels (0.001mg/L and 0.005mg/L). the average recovery for the vast majority of the organotins was between 70.0% to 120.0% with the relative standard deviation less than 10.0%. the method was found to be simple, fast and sensitive. It can be used for the trace analysis of multiple organotin compounds in beverages for both qualitative and quantitative analysis.
Publication number: 5991-4434EN.pdf
Publication Date: April 15, 2014