Investigations on storage-induced changes of the red blood cell lipidome

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    Application note

    Doping Control

     

    Abstract

    Lipid biomarkers for RBC storage lesions could be potentially used to develop direct detection strategies for autologous blood doping. Within this study, two complementary approaches for the analysis of the RBC lipidome were developed by using high performance liquid chromatography/time-offlight mass spectrometry (HPLC/TOF-MS) and gas chromatography/time-offlight mass spectrometry (GC/TOF-MS). The applicability of both approaches was demonstrated by analyzing an exemplary set of four blood samples which were stored ex vivo for a period of 42 days.

     

    Publication number: 5991-5939EN

    Publication Date: April 10, 2015

     

    http://www.agilent.com/cs/library/applications/mdopingcontrol_AppNote_redbloodlipidome.pdf