Analysis of Extractable/Leachable Compounds from Transdermal Patches Using GC/MSD Systems

Version 1

    Application Note

    Pharmaceutical

     

    Abstract

    A lidocaine adhesive patch and film release liner were used to investigate extractable and leachable compounds in transdermal drug delivery systems using two Agilent 5977A Series GC/MSD Systems. Plastic and adhesive additives were identified in acetone, dichloromethane, and hexane extracts using the large volume liquid injection technique. Pharmaceutical ingredients were also identified using high temperature headspace and liquid sampling techniques.

     

    Publication number: 5991-5605EN.pdf

    Publication Date: July 22, 2015

     

    http://www.agilent.com/cs/library/applications/5991-5605EN.pdf