Analysis of Extractable/Leachable Compounds from Generic Liquid Drug Formulations Using GC/MSD Systems

Version 1

    Application Note



    Pharmaceutical liquid formulations are commonly stored in plastic containers at all risk categories. A pharmaceutical suspension was used as model for investigating compound migration from packaging material. Two Agilent 5977A Series GC/MSD Systems were used. Fatty acid plasticizers were identified using the 7697A Headspace Sampler and a 7890A GC coupled with a 5977A MSD. Phthalate plasticizers were found using the MMI 7890A GC coupled with a 5977A MSD. Single ion monitoring (SIM) confirmed the identification of these plasticizers.


    Publication number: 5991-5632EN.pdf

    Publication Date: March 30, 2015