Analysis of Extractable/Leachable Compounds From Plastic Intravenous Bag Sets Using GC/MSD Systems

Version 1

    Application Note

    Pharmaceuticals

     

    Abstract

    Two Agilent 5977A Series GC/MSD Systems were used for the analysis of extractable and leachable compounds in plastic IV bag sets. Two types of IV bags were investigated: 150-mL dextrose bag (expired) and 1-L sodium chloride bag (warmed). Potentially toxic additives, such as phthalate plasticizers, were shown to have migrated from the IV bag to its infusion solution using the complementation of headspace sampling and liquid injection techniques. High temperature analysis was accomplished using the 7697A Headspace and a 7890A GC coupled with a 5977A MSD. Solvent extracts were analyzed using the MMI 7890A GC coupled with a 5977A MSD. Single ion monitoring (SIM) was used to confirm compound migration.

     

    Publication number: 5991-5616EN.pdf

    Publication Date: July 22, 2015

     

    http://www.agilent.com/cs/library/applications/5991-5616EN.pdf