A pressurized metered-dose inhaler (pMDI) is an inhalation device developed for the direct delivery of active pharmaceutical ingredient (API) to the respiratory tract for the treatment of respiratory conditions. Rubber and plastic components in the pMDI are potential sources of extractables by the API/propellant. Therefore, volatile and semivolatile extractable compounds were investigated in these components using two 5977 GC/MSD systems. This application note focuses on identifying extractables in the pMDI using the complementation of headspace GC/MS and MMI GC/MS.
Publication number: 5991-6142EN.pdf
Publication Date: October 9, 2015