Dear LC users,
I'm doing a research on replacing CMR solvents for SEC HPLC analysis. (we are using chloroform and THF currently).
I was wondering if anyone has experience on using Gamma-valerolactone as a solvent for HPLC/SEC?
I am planning on using a PLgel MIXED-D, 7.5 x 300 mm, 5 µm, HPLC column in combination with a 1260 Infinity II ELSD detector from Agilent. (and a Agilent HPLC).
Are there any parts that could be damaged by the nature of this chemical?
Any other things to keep in mind?
(I already plan on optimizing column flow/temperature and ELSD temperature/gas flow)
Opinions or tips and tricks are very welcome!