I am trying to figure out the best way to perform alcohol determination on alcohol pre-moistened wipes with respect to USP <611>. What would be the best way to extract the alcohol from the pads for quantification?
Anyone have experience with this?
I am trying to figure out the best way to perform alcohol determination on alcohol pre-moistened wipes with respect to USP <611>. What would be the best way to extract the alcohol from the pads for quantification?
Anyone have experience with this?
Hi Chemist 123,
FTIR has proven to be a fast and easy solution to quantify alcohol in hand sensitizers. I think it could also be applied to alcohol wipes. If you use an ATR accessory you could even measure the wipes directly without any extraction.
All you would need is a series of wipes with known alcohol content (as standards) covering the concentration range you are interested in. Next, measure FTIR spectra of these wipes and create a calibration curve based on a suitable peak in the spectrum (e.g. ca. 1050 cm-1 for ethanol and ca. 1130 cm-1 for isopropanol). The calibration curve can then be used to determine the alcohol concentration in your wipe samples.
I hope that helps.
Fabian
Hi Chemist 123,
FTIR has proven to be a fast and easy solution to quantify alcohol in hand sensitizers. I think it could also be applied to alcohol wipes. If you use an ATR accessory you could even measure the wipes directly without any extraction.
All you would need is a series of wipes with known alcohol content (as standards) covering the concentration range you are interested in. Next, measure FTIR spectra of these wipes and create a calibration curve based on a suitable peak in the spectrum (e.g. ca. 1050 cm-1 for ethanol and ca. 1130 cm-1 for isopropanol). The calibration curve can then be used to determine the alcohol concentration in your wipe samples.
I hope that helps.
Fabian