Method for meHg

Hello Sanjay,

Methyl mercury can be determined using ICP-Ms by coupling a HPLC to the front of the instrument.
The column of the HPLC can separate the different mercury species in time (including methyl mercury) to enable their determination using the ICP-MS.

Agilent has published some application notes that outline methods for determination of methyl mercury and other species in a number of sample matrices.
Although these do not match the sample type you asked about, they should provide broad guidance for how to tackle this. See this application for example:

Title:
Fast and Accurate Speciation of Mercury in Milk and Honey Food Products by HPLC-ICP-MS

Available from the Agilent website here:
https://www.agilent.com/cs/library/applications/application-milk-and-honey-7850-icp-ms-5994-3628en-agilent.pdf

There are also some journal articles available that can be of assistance. See this article for example:

Title:
Tin and mercury and their speciation (organotin compounds and methylmercury) in worldwide red wine samples determined by ICP-MS and GC-ICPMS

Link:
https://www.researchgate.net/profile/Ekaterina-Epova-2/publication/339819450_Tin_and_mercury_and_their_speciation_organotin_compounds_and_methylmercury_in_worldwide_red_wine_samples_determined_by_ICP-MS_and_GC-ICP-MS/links/62503895d726197cfd46d179/Tin-and-mercury-and-their-speciation-organotin-compounds-and-methylmercury-in-worldwide-red-wine-samples-determined-by-ICP-MS-and-GC-ICP-MS.pdf

I hope these references can get you started - but let us know if you need further assistance,
Cheers Eric

Hello Sanjay,

Methyl mercury can be determined using ICP-Ms by coupling a HPLC to the front of the instrument.
The column of the HPLC can separate the different mercury species in time (including methyl mercury) to enable their determination using the ICP-MS.

Agilent has published some application notes that outline methods for determination of methyl mercury and other species in a number of sample matrices.
Although these do not match the sample type you asked about, they should provide broad guidance for how to tackle this. See this application for example:

Title:
Fast and Accurate Speciation of Mercury in Milk and Honey Food Products by HPLC-ICP-MS

Available from the Agilent website here:
https://www.agilent.com/cs/library/applications/application-milk-and-honey-7850-icp-ms-5994-3628en-agilent.pdf

There are also some journal articles available that can be of assistance. See this article for example:

Title:
Tin and mercury and their speciation (organotin compounds and methylmercury) in worldwide red wine samples determined by ICP-MS and GC-ICPMS

Link:
https://www.researchgate.net/profile/Ekaterina-Epova-2/publication/339819450_Tin_and_mercury_and_their_speciation_organotin_compounds_and_methylmercury_in_worldwide_red_wine_samples_determined_by_ICP-MS_and_GC-ICP-MS/links/62503895d726197cfd46d179/Tin-and-mercury-and-their-speciation-organotin-compounds-and-methylmercury-in-worldwide-red-wine-samples-determined-by-ICP-MS-and-GC-ICP-MS.pdf

I hope these references can get you started - but let us know if you need further assistance,
Cheers Eric